Alteração da citotoxicidade em células PC12 expostas cronicamente a drogas estimulantes ou ao peróxido de hidrogénio

As drogas de abuso induzem características apoptóticas em células PC12

Efeitos tóxicos de drogas de abuso opióides e estimulantes

Publicações

Ver todas as publicações na Pubmed

Lista de publicações:

Cellular and Molecular Mechanisms Involved in the
Neurotoxicity of Opioid and Psychostimulant Drugs
Teresa Cunha-Oliveira, A. Cristina Rego, Catarina R. Oliveira
Brain Research Reviews, in press, 2008 Mar 27
DOI: 10.1016/j.brainresrev.2008.03.002
PMID: 18440072

Changes in the Activity of Antioxidant Enzymes 
in PC12 Cells Chronically Exposed to Psychostimulants
T. Cunha-Oliveira, A.C. Rego, T. Macedo and C.R. Oliveira
Proceedings of the European Meeting of the Society for Free
Radical Research, October 2007, Medimond International Proceedings, 

Street heroin induces mitochondrial dysfunction 
and apoptosis in rat cortical neurons.
J Neurochem. 2007 Apr;101(2):543-54. Epub 2007 Jan 23

Efeito crónico da heroína e do peróxido de hidrogénio em células PC12
Coimbra Médica (V série). 2006 Nov; vol 2 pp 21-29

Expression of NR1/NR2B N-methyl-D-aspartate 
receptors enhances heroin toxicity in HEK293 cells.
Ann N Y Acad Sci. 2006 Aug;1074:458-65.

Synthesis and cytotoxic profile of 3,4-methylenedioxy-
methamphetamine ("ecstasy") and its metabolites on 
undifferentiated PC12 cells: A putative structure-toxicity
relationship.
Chem Res Toxicol. 2006 Oct;19(10):1294-304. 

Mitochondrial Dysfunction and Caspase Activation in Rat Cortical
Neurons Treated with Cocaine or Amphetamine
Brain Res 2006; 1089 (1) 44-54

Differential cytotoxic responses of PC12 cells chronically exposed to
psychostimulants or to hydrogen peroxide.
Toxicology. 2006 Jan 5;217(1):54-62. Epub 2005 Oct 19.

Drugs of abuse induce apoptotic features in PC12 cells.
Ann N Y Acad Sci. 2003 Dec;1010:667-70.

Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells.
Ann N Y Acad Sci. 2002 Jun;965:487-96.

Multimedia

3D Movies

3D animation: (2007) TERESA CUNHA-OLIVEIRA and A. Cristina Rego. Mitochondrial apoptotic pathway, in: "Interactions Between Neurons and Glia in Aging and Disease", Springer, Malva, J.; Rego, A.C.; Oliveira, C.; Cunha, R. (Eds.), ISBN: 978-0-387-70829-4

3D animation: (2007) A. Cristina Rego, TERESA CUNHA-OLIVEIRA and Luis P. de Almeida. Molecular mechanisms of Huntington´s disease neuropathology, in: "Interactions Between Neurons and Glia in Aging and Disease", Springer, Malva, J.; Rego, A.C.; Oliveira, C.; Cunha, R. (Eds.), ISBN: 978-0-387-70829-4